Pharmacological properties Loratadine 10 mg
Pharmacodynamics. Loratadine The long-acting antihistamine. Loratadine selectively blocks peripheral histamine H1-receptors, produces a complex (anti-allergic, antipruritic and antiexudative) effect. Unlike other antihistamines, does not have a sedative effect, as it does not cross the BBB. Decreases capillary permeability, smooth muscle spasm resolves, prevents the development of edema. Do not have teratogenic, mutagenic and carcinogenic effects.
Pharmacokinetics. Rapidly absorbed after oral administration, after 15 min determined in the blood and reaches its maximum concentration within 1 h after a single dose. Antiallergic, antipruritic antiexudative and effects of the drug develops in 30-60 minutes, reach a maximum after 8-12 hours Duration – 24 hours almost completely bound to plasma protein – up to 97%. When biotransformation into active metabolite – deskarboetoksiloratadin. The half-life – 3-20 hours, the active metabolite – 8,8-92 h. Food intake did not affect the pharmacokinetics of the drug, but lengthens the time to reach maximum concentration at 1 h, and the drug is recommended to take before meals. Chronic renal failure, liver dysfunction have no significant effect on the pharmacokinetics of the drug. Loratadine is excreted in the urine and feces.
Statement Loratadine 10 mg
treatment of symptoms of seasonal and perennial allergic rhinitis (sneezing, itching, nasal mucosa, rhinorrhea, itching and burning sensation in eyes, watery eyes), chronic idiopathic urticaria, allergic skin disease genesis.
Application Loratadine 10 mg
inside to eat.
For children weighing ≥ 30 kg – 1 tablet (10 mg) per day.
Adults and children over the age of 12 years – 1 tablet (10 mg) per day.
Treatment course – 10-15 days and in some cases set individually – from 1 to 28 days.
Contraindications Loratadine 10 mg
Hypersensitivity to loratadine, pregnancy and lactation. In children under 3 years old used the drug in different dosage form.
Side Effects Loratadine 10 mg
Adverse events occurred with approximately the same frequency as in the use of a placebo. In adults, headache, extreme tiredness, dry mouth, drowsiness, nausea, gastritis, allergic reactions (hives), anaphylaxis, alopecia, abnormal liver function. Children: headache, nervous irritability, sedatsiya.Peredozirovka. Symptoms: drowsiness, tachycardia, headache. Treatment: gastric lavage, activated charcoal.
sometimes be a feeling of dryness in the mouth, nausea, and vomiting.
Cautions Loratadine 10 mg
elderly patients and with abnormal liver function / kidney increases the risk of side effects, so when using the drug at recommended doses in these patients may develop side effects such as drowsiness.
Despite the fact that Loratadine is not sedating antihistamine, some patients note the dose-dependent sedation.
The drug has no effect on heart rate and blood pressure.
In alcoholic liver disease the maximum concentration of drug in plasma and blood half-life increases in proportion to increasing disease severity.
Should refrain from driving and working with potentially dangerous machinery to determine the individual response to the drug.
Interactions Loratadine 10 mg
cimetidine, erythromycin and ketoconazole increase the concentration of drug in blood plasma. Due to the possible development of dose-sedative effect should be careful when applying to other blockers of H1-receptors, barbiturates, benzodiazepines, opioid receptor agonists, neuroleptics, tricyclic antidepressants, ethanol, anxiolytics, sedatives and hypnotics.
Overdose Loratadine 10 mg
Symptoms include headache, drowsiness, and tachycardia.
Treatment is symptomatic (cause vomiting, activated charcoal is used.) Hemodialysis is not effective.
